You’ve got lots of RAM, so you shouldn’t need to do anything special for 10 nodes. If they’re new perhaps try vanilla ext4 with the new hashstore flags (which aims to reduce small random IO). It’s experimental but apparently it’s working well for Select operators.
If you have a pair of SSDs (devices, or partitions), many also run the standard piecestore setup with ZFS, specifically to use the special-metadata device. Because Storj has millions of .sj1 files per TB, it really benefits from having all that metadata on flash.
Oh and it’s pretty common to have your node databases on flash too. Many people already have a SSD as their boot device with lots of spare space: may as well redirect the DB files there.