The first one is related to your disk is too slow. The second one (with canceled uploads) is likely related to the same problem too, but usually it’s mean that your node is too slow to accept the upload and the customer canceled it. The third error again related to your slow disk, but now this affect databases also.
I would recommend to stop the node, check the disk for errors and fix them. If this is NTFS, you also need to perform a defragmentation and enable the automatic defragmentation for this disk (it’s enabled by default).
If you use any network filesystem (SMB/CIFS, NFS, etc.), then you need to migrate to iSCSI or run your node directly on your file server.
To help databases to be not locked you need to move them to SSD, if the problem with the slow disk would not be fixed by suggestions above.
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