I use BTRFS without issues now, but I had to disable future CoW and remove CoW from my existing files. My current BTRFS /etc/fstab settings are: defaults,nofail,noatime,nodiratime,nodatacow,noautodefrag.
I ultimately had to disable CoW, shutdown my node, move the data, and copy it back (rewrite without CoW), then restart the node. I also tried a defrag before this (in theory it would allow you to do everything with the node online, but that was essentially locking up my node (watch your RAM usage balloon when the drives get slow).