looks like there are problems with MTU. I have a connection with lower then 1500byte MTU. I don’t know why this probleme only some times and not all the time. I have fix it with
iptables -t mangle -A POSTROUTING -p tcp --tcp-flags SYN,RST SYN -o $IFACE -j TCPMSS --clamp-mss-to-pmtu
on both site from the lower MTU connection
looks like that work now