I think these are huge problems, that can’t be overcome.
Especially, if you’re searching in previous posts you see many problems arose with people using ext4. Especially those, who used 200TiB volumes, symbolic links and those who tried to download 16TiB segments from storj. You won’t find any of those people and nodes still alive… 
But really, why’re you asking if ext4 is one of the best recommended file systems. Opposed to for example fat, exfat or btrfs? See the many examples, if you were able to find the search function. Such like 1 and 2.