Maximum Node size?

I have a 40 TB Root Server. Is it besser to run one node with 40 TB or is it wise to run in this case e.g. 4 Nodes with 10 TB on this Root Server

Better to run 1 Node per HDD, but if you run them at same time vetting will be very long. then you can start them 1 by 1, as first veeted, start second. Thay will share trafic, but if 1 node is broken, you not loose all nodes.

Just curious, how much of the 40 TB is full so far? Do you backup your database files just in case?

No the 40 TB are not full. Just 100 GB